P3: cGMP-dependent regulation of cell and tissue mechanics

To earn her Bachelor’s Degree (BSc), Marina studied Medical Engineering at the University of Tübingen and the University of Stuttgart. After that, she focused more on the biological part of Medical Engineering and continued with her Master’s Degree (MSc) in Biomedical Technologies at the University of Tübingen. During the master’s program, Marina developed a deeper interest in biophysics, as it was one of her focus areas. After gaining some industry experience through internships and her Master's thesis, Marina decided to further expand her knowledge. Starting in September, she is going to work on her PhD in the laboratory of Prof. Dr. Tilman Schäffer, where she will investigate the role of cGMP in tissue mechanics. 

Daniel Lambton earned his BSc in Nano-Science at the University of Tübingen. During his Bachelor thesis, he studied the motility of kinesin motors along the microtubule network with the goal of further understanding the transport complex for mitochondria. Following up on his Bachelor thesis, Daniel began the MSc in Nano-Science at the University of Tübingen, where he gained further interest in biophysics. In his Master thesis, he adapted an Atomic Force Microscope with a force sensor to characterise the viscoelastic properties of larger tissue samples. Now, he has begun his PhD in the laboratory of Prof. Dr. Tilman Schäffer where he continues to investigate the role of the cGMP signalling pathway in the mechanics of tissues.

Johanna Rodríguez earned her BSc (Hons) in Pharmacology & Physiology at the University of Manchester (United Kingdom). During her bachelor thesis, she focused on the study of selective inhibitors of Tyrosine Phosphatases through docking and protein structural analysis. After her bachelor, she did an Erasmus Mundus Joint Master Degree in Nanomedicine for Drug Delivery with a specialization in “Production and Biotechnology applications of Nanomedicine”. She completed her first year of MSc at University Paris Descartes (France) and her second year at the University of Pavia (Italy). In her master’s thesis she studied the “Design, development, and characterisation in-vitro of theranostic nanobubbles for the treatment of pancreatic cancer” in the laboratory of Pharmaceutical Technology at the University of Turin (Italy). Recently, Johanna has joined the laboratory of Tilman Schäffer to do her doctoral studies. Here, her research focuses on cGMP signalling pathway, cardiovascular diseases, vascular biomechanics, and knockout mice in-vivo models.

Aylin Balmes earned her BSc in Nano-Science at the University of Tübingen. During her bachelor thesis she studied the migration of blood platelets with phase contrast microscopy. After her bachelor she did the corresponding MSc in Nano-Science also at the University of Tübingen. With her elective courses she focused mostly on physics, especially biophysics. In her master thesis she studied the viscoelastic properties of cells with scanning ion conductance microscopy. On the side she is also pursuing a BSc in Physics. Aylin is now pursuing a PhD in the laboratory of Prof. Dr. Tilman Schäffer where she investigates the role of cGMP from a physics point of view.

Aylin graduated in December 2024 and subsequently received start-up funding to support his further career as a potdoc at the IFIB (see also here).

Hendrik von Eysmondt developed an interest in biophysics early in his B.Sc. of Biology at the RWTH Aachen, Germany, leading to a Bachelor thesis about the unidirectional growth of neuronal axons with microfluidics at the Institute of Biological Information Processing - Bioelectronics (IBI-3) at the Forschungszentrum Jülich.
He continued his studies in Aachen, obtaining his M.Sc. in Biology with a Master thesis in the adaptation of the sFIDA assay for an amyloidogenic protein in type 2 diabetes in his work at the Institute of Complex Systems 6 (ICS-6) at the Forschungszentrum Jülich. 
Recently, he has joined the lab of Prof. Dr. Tilman Schäffer at the University of Tübingen to obtain his PhD, focusing on the mechanical properties of blood platelets, especially in the context of lipid interactions.

Konstantin Krutzke gained his interdisciplinary knowledge in natural sciences during his BSc in Nano-Science at the University of Hamburg. For his bachelor thesis he investigated the removal of cytotoxic CTAB of gold nanorods for possible biological applications such as medical diagnostics or treatments. For his ongoing scientific career, he accomplished his MSc in Nano-Science at University of Hamburg in the field of micro-fluidics at the department of applied physics. He investigated the implementation of micro-fluidic, PDMS based nozzles for single particle imaging at the Hamburg based DESY as well as at research facility EuXFEL. For his doctoral studies Konstantin joined the lab of Prof. Dr. Tilman Schäffer at the University of Tübingen to investigate human thrombocyte volume changes with SICM in response to osmotic pressure.

Jan Seifert studied physics at the University of Erlangen with focus on medical physics. For his diploma thesis he joined the lab of Prof. Tilman Schäffer and obtained knowledge about scanning probe microscopy in biological and medical applications. During his PhD he investigated shape changes and cytoskeletal dynamics in human platelets during activation with fast scanning ion conductance microscopy. As a postdoc, he gained interest in machine learning and currently focuses on the application of deep learning neural networks in optical platelet morphometry and the implementation of deep learning for measurement automation in scanning probe microscopy.