Sub-project A01: Generation of specificity in the post-Golgi trafficking: The role of ARF-GEFs and ARFs for cargo selection
Principle Investigator:
Prof. Dr. Gerd Jürgens
Universität Tübingen
ZMBP, Entwicklungsgenetik
Auf der Morgenstelle 3, 72076 Tübingen
Tel 07071 – 29 78886
Fax 07071 – 29 5797
gerd.juergens@zmbp.uni-tuebingen.de
Summary:
Project A01 addresses the contributions made by guanine-nucleotide exchange factors for small ARF GTPases (ARF-GEFs) to the generation of specificity in membrane traffic between compartments of the post-Golgi endomembrane system. Within the same cell, different proteins are simultaneously secreted, trafficked to the vacuole, endocytosed or recycled. Cargo proteins are sorted during the formation of a transport vesicle, which appears to involve - depending on the specific process - different ARF-GEFs and (possibly corresponding) ARFs.