Sub-project B02: From fluctuating developmental signals to stable stem cell behavior
Principle Investigator
Prof. Dr. Jan Lohmann
Universität Heidelberg
Centre for Organismal Studies Stammzellbiologie
Im Neuenheimer Feld 230, 69120 Heidelberg
Tel 06221 - 54 6269
Fax 06221 - 54 6424
jan.lohmann@cos.uni-heidelberg.de
Summary
From fluctuating developmental signals to stable stem cell behavior
TP B02 will study how fluctuating developmental signals are translated into stable stem cell behavior. The project will focus on the mechanisms of information processing by A-Type ARABIDOPSIS RESPONSE REGULATORS (ARRs), which integrate Auxin and Cytoknin stimuli and relay these signals to the stem cell regulator WUSCHEL. Starting point of the proposed experiments is the hypothesis that via a direct interaction with Class I Topoisomerases A-Typ ARRs exert their gene regulatory function by locally modulating chromatin structure.